Sara and Tré lost a combined 160 pounds, but some of their most dramatic changes were invisible: testosterone more than doubled, celiac antibodies fell substantially, and insulin-related markers improved significantly.

AUSTIN, Texas, Oct. 20, 2026 /PRNewswire/ — Function, the health company on a mission to empower 100 healthy years for all, today announced its partnership with MrBeast as the featured health partner in his latest YouTube video. The video follows Sara and Tré through what MrBeast describes as “the biggest transformation on YouTube,” with Function’s advanced lab testing revealing changes in their health beyond the scale.

The engaged couple entered the challenge for the chance to win $250,000. But behind the prize were hopes that made the journey deeply personal. Sara wanted to be healthy enough to start a family. Tré pictured himself running around with their children, with the energy to keep up. Both wanted the energy and health to build that life together.

Before the challenge, they were inactive and exhausted. Through advanced lab testing with Function, Sara and Tré uncovered underlying health concerns that went far beyond their weight. When Function Co-Founder and Chief Medical Officer Mark Hyman, M.D. reviewed their results, the couple began to understand what was happening inside their bodies.

Tré, 29 years old, learned that his testosterone measured 160, a level Hyman compared to that of a 90-year-old, alongside markedly elevated insulin-related markers that signaled the onset of prediabetes. Sara, 27, had elevated insulin-resistance markers and celiac antibodies, along with PMOS, a hormonal condition that can affect ovulation and fertility. The findings gave new urgency to the future they hoped to build together.

By day 75, Tré’s insulin had decreased 83%, and Sara’s had decreased 82%. For Sara, those tangible results became a powerful source of motivation. When the couple felt discouraged, MrBeast used follow-up lab testing to show them that their efforts were accomplishing much more than weight loss.

Later in the challenge, Hyman returned to review their progress. Tré’s total testosterone had more than doubled, rising from 160 to 356. Sara’s tTG-IgG, a celiac antibody marker, had fallen from 41.0 to 8.1, while her insulin resistance score dropped from 77 to 9.9. In 163 days, they had lost a combined 160 pounds. Beyond the numbers, they described a profound change in their daily lives: more energy, feeling better, and renewed excitement for the future they were building together.

“The weight loss was huge, but each time we reviewed our biomarkers, I could see how much more was changing,” said Sara. “I wasn’t just changing how I looked. I was seeing improvements in the health that had worried me most. It gave me hope that my health didn’t have to define my future.”

The couple rebuilt their daily lives around their health. Frequent takeout gave way to home-cooked meals, more protein, and fewer processed foods. With their trainers, they made strength training and regular movement a daily commitment. They prepared meals together, pushed through demanding workouts and challenges, and kept each other going when motivation faded. Over time, those choices became habits, giving them the strength, energy, and confidence to imagine a different future.

“For the first time, I knew what I needed to work on and had proof that the work was paying off,” said Tré. “I feel like we have our lives back.”

The partnership brings Function’s advanced lab testing to MrBeast’s health challenge, revealing the transformation beyond the before-and-after photos. The scale showed how much weight Sara and Tré lost. Their lab results revealed how profoundly key markers of their health had changed.

“Sara and Tré’s experience is a powerful reminder that weight is only one measure of health,” said Hyman. “When you can see your biology clearly, you can make informed changes and watch those changes take hold.”

For Sara and Tré, the finish line is not the video or the prize. It is the future they can now picture: more energy, more movement, and the chance to build a long, active life together.

Watch the video on MrBeast’s YouTube channel at youtube.com/@MrBeast. Learn more at functionhealth.com.

About Function

Function is on a mission to enable everyone to live 100 healthy years. A groundbreaker in its category, Function has changed the game by making lab testing, MRI and CT, and longitudinal health data accessible, understandable, and actionable—serving millions. Function’s Medical Intelligence Lab™ (MI Lab™) is leveraging a dedicated clinical team to develop a continuous learning system that helps its members see, understand, and act on their biology over time. Members receive access to 160+ lab tests—including biannual testing—for just $365/year, equivalent to $1 per day, covering the heart, hormones, thyroid, liver, kidneys, heavy metal exposures, nutrient levels, inflammation, potential cancer signals, and more. Each member’s results are integrated into an intelligent, personalized interface designed to support powerfully informed decision-making. Function members can also access (for an additional cost) MRI and CT that are designed to see signals of cancer and hundreds of other conditions. Through its acquisition of SuppCo, Function is also bringing greater trust and clarity to supplements, helping members better understand and manage what they put in their bodies. Function believes everyone should have the power to own their health.

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SOURCE Function Health